Sponsoring Company: Center for BioMolecular Modeling

COVID 19: Science to the Rescue! The COVID19 pandemic has created many challenges for educators over the past two years. Amidst all this chaos, there is one positive outcome of this pandemic – it has provided educators in the molecular biosciences with an opportunity to highlight the power of modern biology and the many ways in which this science has been used to provide solutions to the control of this virus. This workshop will tell the story of the COVID19 pandemic from the perspective of the CoV-2 virus, the structure of the spike protein, the molecular mechanism of the infections process and the successful application of an mRNA vaccine to provide protection from infection. Workshop participants will use physical models of the CoV-2 coronavirus – enhanced by Augmented Reality – to explore these topics.

TAKEAWAYS:
The nucleotide sequence of the CoV-2 RNA genome was the first step in vaccine development.

SPEAKERS:
Tim Herman (3D Molecular Designs: Milwaukee, WI)

Sponsoring Company: Edvotek

Respiratory viruses like influenza or COVID can lead to worldwide pandemics. We’ll discuss how diseases spread and perform experiments to explore how disease testing works.

TAKEAWAYS:
Attendees will explore pathology of common diseases, including clinical testing and epidemiology of pathogens.

SPEAKERS:
Brian Ell (Edvotek Inc.: Washington, DC), Danielle Snowflack (Edvotek Inc.: Washington, DC)

Sponsoring Company: Vernier Software & Technology

Get active and participate in hands-on experiments. Explore limb position and grip strength, balance, and EKGs/EMGs experiments designed to encourage students to think about the physiology of various human organ systems. Walk away with valuable information, including sample labs and teaching tips.

TAKEAWAYS:
1. Gain experience with hands-on technology that encourages students to explore and test different solutions and make connections to the real world; 2. Get access to free resources to keep students engaged while learning key scientific concepts either remotely or in the lab; and 3. Gain hands-on experiences with innovative products that increase student engagement, promote creativity and collaboration, and develop problem-solving skills.

SPEAKERS:
Colleen McDaniel (Vernier Science Education: Beaverton, OR), Nüsret Hisim (Vernier Science Education: Beaverton, OR)

Sponsoring Company: Edvotek

Want to learn today’s top biotechnology techniques? Join us for a hands-on exploration of PCR and electrophoresis in one hour using the EdvoCyclerJr and the EDGE!

TAKEAWAYS:
Attendees will explore the science behind the polymerase chain reaction (PCR) and learn strategies for performing PCR in short class periods.

SPEAKERS:
Brian Ell (Edvotek Inc.: Washington, DC), Danielle Snowflack (Edvotek Inc.: Washington, DC)

Sponsoring Company: Texas Instruments

Attendees will explore disease modeling through the use of real (virtual) ZOMBIES!

TAKEAWAYS:
1. This session will explore disease-spread modeling using fictional zombies; 2. Attendees will also see how using Hollywood themes combined with actual STEM careers can be a fun way to engage students in learning science and STEM; and 3. Attendees will find out about free science and STEM lessons from Texas Instruments.

SPEAKERS:
Jeffrey Lukens (Retired Science Teacher: Sioux Falls, SD)

Sponsoring Company: 3D Molecular Designs

Participants will examine the structure of phospholipids and how it shapes the function of the cell membrane using multiple representations including hands-on models. Cellular processes like active and passive transport will be explored while demonstrating how these models can amplify traditional biology labs and classroom activities. Participants will explore examples of membranes in action that can be applied to units on genetics and evolution to extend the reach of the models throughout the school year.

TAKEAWAYS:
Students can create and revise models to explore how the structure of phospholipids influences the function of cell membranes.

SPEAKERS:
Kim Parfitt (3D Molecular Designs: Milwaukee, WI)

Sponsoring Company: Texas Instruments

An empty field. A human corpse. Maggots and flies. Who is the victim? What happened? Can you solve the mystery? This middle and high school activity will challenge you to apply science and deductive reasoning to determine what happened!

TAKEAWAYS:
1. Forensic science is a STEM career field that combines science, math, and criminal justice concepts; 2. Understanding the natural process of decomposition can help investigators narrow in on identifying victims and causes of death; and 3. Using stories is a great way to engage students and provide context to the science/STEM they are learning.

SPEAKERS:
Jeffrey Lukens (Retired Science Teacher: Sioux Falls, SD)

Sponsoring Company: Edvotek

Forensic science combines disciplines to determine “whodunit.” In this workshop, learn how to merge hands-on biotechnology experiments with literacy exercises to create an immersive lesson.

TAKEAWAYS:
Attendees will perform hands-on biotechnology experiments that will allow them to discuss the implications of genetic fingerprinting and blood testing of forensic samples in class.

SPEAKERS:
Brian Ell (Edvotek Inc.: Washington, DC), Danielle Snowflack (Edvotek Inc.: Washington, DC)

Sponsoring Company: 3D Molecular Designs

During this workshop, participants will work explore cell communication using hands-on models of synapses. Participants will experience how using models to explore abstract concepts deepens student understanding and inquiry for students and provides opportunities for formative assessments of student understanding. Participants will also have opportunities to deepen and challenge their own conceptual understanding of cell communication by altering the biochemical events within the synapses. These changes will reflect what happens when synapses are disturbed by drugs, including both prescription and drugs of abuse, as well as some mental health disorders. Finally, ideas for three-dimensional summative assessments will be explored.

TAKEAWAYS:
Hands on models of synapses let students explore cell communication and the structure and function relationship of proteins and signaling molecules including toxins and drugs.

SPEAKERS:
Kim Parfitt (3D Molecular Designs: Milwaukee, WI)

Sponsoring Company: Edvotek

Explore the science of candy colors! In this hands-on workshop, we’ll use electrophoresis and chromatography to separate mixtures of molecules based on their physical properties.

TAKEAWAYS:
Attendees will explore the physical properties of molecules using chromatography and electrophoresis.

SPEAKERS:
Brian Ell (Edvotek Inc.: Washington, DC), Danielle Snowflack (Edvotek Inc.: Washington, DC)

Sponsoring Company: Fisher Science Education & Aldon

Looking for ways to connect your classroom, regardless of whether students are in school or at home? Co-lab-orate is an innovative digital lab notebook that allows educators to easily create, assign, and grade lab reports, while helping students communicate with their classmates and teachers. Co-lab-orate can be used to complete hands-on activities done individually or in a group setting, when working at school or remotely. Join Fisher Science Education and Aldon as we conduct an experiment while showcasing Co-lab-Orate’s game changing and cost-effective teaching platform!

TAKEAWAYS:
Attendees will perform a lab experiment and record the results on their own device experiencing the full power of Co-Lab-Orate.

SPEAKERS:
Kymberly Hall , Alex Molinich (Aldon Corporation: Avon, NY)

Sponsoring Company: miniPCR bio

Bring authentic CRISPR/Cas9 to your class in the most easy-to-implement format possible. Use Cas9 enzyme paired with different guide RNAs to target specific DNA sequences. Use sequence analysis to predict where Cas9 will cut, then perform the experiment and compare predictions to results using DNA gel electrophoresis. Get to the heart of CRISPR/Cas9 function without the need for live organisms or complicated procedures. Real CRISPR/Cas is more accessible than you ever thought possible!

TAKEAWAYS:
Use real Cas9 enzyme to target and cut DNA with clear gel electrophoresis readouts to view results.

SPEAKERS:
Bruce Bryan (miniPCR: Cambridge, MA)

Sponsoring Company: Beyond Labz

Workshop Summary: Beyond Labz is a set of sophisticated and realistic virtual laboratories that have been used by millions of students over the past 20 years. Subjects covered by the virtual labs include general chemistry, organic chemistry, physics, physical science, and biology. We have recently updated the virtual labs so they are browser-based with a number of new features including tracking student lab books and the student journey through the lab. With over 20 years of experience and feedback from students and teachers worldwide, we have learned much about how to enhance and augment classroom and laboratory instruction using the virtual labs. In this presentation we will provide a brief update on the new features in Beyond Labz, and we will provide onboarding instructions and describe how to use the virtual laboratories in various curriculum settings and use cases, and we will show the labs can be used to enhance inquiry-based instruction. We will also describe some of the recent research we have performed using these and other simulation products we have created.

TAKEAWAYS:
Beyond Labz simplifies and reduces the cost and expertise needed to provide crucial laboratory experiences and practice for Secondary and Higher Ed students. Attendees will learn how the labs are used for pre and post lab experiences, credit recovery and lab make-up, student engagement in class, and meeting NGSS standards. Basic onboarding and startup instructions will be provided for drop-in solutions, and instructions for using some of the more sophisticated features will also be described.

SPEAKERS:
Brian Woodfield (Brigham Young University: Provo, UT)

Sponsoring Company: Vernier Software & Technology

Stop counting bubbles. It has never been easier to visualize photosynthesis in the classroom. Use the latest technology to measure photosynthesis and the variables that affect it. Bring your own device with our Graphical Analysis app installed or use our devices. All activities are available as a free download for attendees.

TAKEAWAYS:
1. Gain experience with hands-on technology that encourages students to explore and test different solutions and make connections to the real world; 2. Get access to free resources to keep students engaged while learning key scientific concepts either remotely or in the lab; and 3. Gain hands-on experiences with innovative products that increase student engagement, promote creativity and collaboration, and develop problem-solving skills.

SPEAKERS:
Colleen McDaniel (Vernier Science Education: Beaverton, OR), Nüsret Hisim (Vernier Science Education: Beaverton, OR)

Sponsoring Company: Edvotek

Explore the relationship between genotype and phenotype using your sense of taste and biotechnology! Examine variations in your bitter taste receptor with PCR and electrophoresis.

TAKEAWAYS:
Attendees will explore the link between genotype and phenotype using PCR and a PTC tasting assay.

SPEAKERS:
Brian Ell (Edvotek Inc.: Washington, DC), Danielle Snowflack (Edvotek Inc.: Washington, DC)

Sponsoring Company: miniPCR bio

Bring your students on an expedition to Madagascar! Analyze morphological data and run electrophoresis gels to determine whether researchers have rediscovered a species of lemur once thought to be extinct. Your students will analyze actual field data, construct phylogenetic trees from DNA sequence data, and compare generalist and specialist species facing ecological change. This collaboration with the Duke Lemur Center was designed with the goal of bringing molecular techniques to Ecology and Evolution units and is based directly on their published and unpublished data. As either a quick, single-period gel electrophoresis lab or a weeklong mini-unit, this lab offers flexibility, engagement, and high-quality curriculum.

TAKEAWAYS:
Bring molecular approaches to ecology and evolution units by exploring authentic data from researchers at the Duke Lemur Center

SPEAKERS:
Bruce Bryan (miniPCR: Cambridge, MA)

Sponsoring Company: Edvotek

HIV is a sneaky virus. Once inside the body, it suppresses the immune system. Learn about testing, tracing, and treatment using a simulated diagnostic ELISA!

TAKEAWAYS:
Attendees will explore medical testing for common diseases, including how they work and what they mean.

SPEAKERS:
Danielle Snowflack (Edvotek Inc.: Washington, DC), Brian Ell (Edvotek Inc.: Washington, DC)

Sponsoring Company: Bio-Rad Laboratories

Outbreak! A new viral disease is spreading rapidly, but how? Analyze patient DNA samples to determine who was infected and figure out how it spreads.

TAKEAWAYS:
1. Walk through a customizable scenario for the classroom in which students use epidemiological techniques to figure out how a novel disease might be spreading; 2. Analyze DNA using agarose gel electrophoresis to determine the infection status of a large set of patients; and 3. See how this adaptable public health and epidemiological puzzle is an excellent context to teach viral disease biology.

SPEAKERS:
Leigh Brown (Bio-Rad Laboratories: Hercules, CA)

Sponsoring Company: miniPCR bio

Furry puppies and Mendelian genetics, two things everybody loves! This activity invites students to trace the inheritance of the furnishings trait (the presence of a mustache and bushy eyebrows in dogs) in a litter of puppies. Molly the labradoodle has had a litter of puppies, but who’s the dad? Is it Otto the labradoodle or Zeus the poodle? Students use Punnett squares to make predictions then run electrophoresis gels to determine the answer. There will be puppy pictures!

TAKEAWAYS:
Connect genotype to phenotype, use Punnett squares to predict inheritance of a Mendelian trait, and run electrophoresis gels to connect modern genetic tools to classical Mendelian inheritance

SPEAKERS:
Bruce Bryan (miniPCR: Cambridge, MA)

Sponsoring Company: Bio-Rad Laboratories

Dig into CRISPR, a revolutionary technology in gene therapy. Learn about a classroom CRISPR lab activity with robust controls and a free paper model.

TAKEAWAYS:
1. Learn about a lab activity in which students do real CRISPR gene editing and confirm the chromosomal edit with PCR; 2. Receive and practice using a free paper model to teach the function of Cas9, a key protein in CRISPR technology; and 3. Hear the latest in CRISPR technology, including current efforts in gene therapy.

SPEAKERS:
Leigh Brown (Bio-Rad Laboratories: Hercules, CA), Tamica Stubbs (Bio-Rad Laboratories: Hercules, CA)

Sponsoring Company: Edvotek

Creating colorful transformed bacteria is an unforgettable way to teach the central dogma of molecular biology. Learn how to use transformed bacteria to create bio-art!

TAKEAWAYS:
Attendees will learn about bacterial transformation and the ways that the technique explores the relationship between genotype and phenotype.

SPEAKERS:
Danielle Snowflack (Edvotek Inc.: Washington, DC), Brian Ell (Edvotek Inc.: Washington, DC)

Sponsoring Company: miniPCR bio

miniPCR bio™ is the leader in bringing PCR and gel electrophoresis into classrooms with affordable, innovative, hands-on tools and activities. Join us to explore how small genetic changes can change our ability to perceive the world around us. The TAS2R38 taste receptor gene can confer the phenotypic ability to taste the chemical phenylthiocarbamide (PTC) and other bitter flavors. Your students can test their own TAS2R38 taste receptor gene and determine whether they have taster or non-taster alleles of the gene. Our most popular lab has been rewritten with updated curriculum appropriate for levels from introductory to AP bio and college. Come learn how our miniPCR® machine and blueGel™ electrophoresis system make classroom biotechnology faster, simpler and more intuitive than ever before.

TAKEAWAYS:
Use affordable hands-on tools to bring PCR and gel electrophoresis to any biology classroom

SPEAKERS:
Bruce Bryan (miniPCR: Cambridge, MA)

Sponsoring Company: Bio-Rad Laboratories

Save native bees! First step, catalog native bee biodiversity. Try out a classroom activity where students use genetic analysis to identify native bee species.

TAKEAWAYS:
1. Learn about a classroom activity in which students learn to identify bee species using entomological tools and genetic methods; 2. Hear the story of the discovery of Bombus incognitus, a recently discovered “look alike” bee native to Colorado; and 3. Learn about how DNA barcoding can be used to identify species that cannot be identified by visual or geographical information.

SPEAKERS:
Tamica Stubbs (Bio-Rad Laboratories: Hercules, CA)

Sponsoring Company: miniPCR bio

The P51TM molecular fluorescence viewer from miniPCR bio allows you to observe molecular processes in ways that were never before possible. With BioBits®, you can put cutting-edge cell-free technology in the hands of your students. Experiment directly with transcription and translation by making RNA and proteins that glow, all without the need for specialized equipment, cell cultures, or time-consuming protocols. Go beyond making models; use fluorescence to light up your biology classroom! Learn how this engaging activity can be scaffolded for students from middle school through college.

TAKEAWAYS:
Use cutting-edge cell-free technology to visualize transcription and translation in real time with no need for living cells and open new area of the molecular biology curriculum to labs using fluorescence visualization

SPEAKERS:
Bruce Bryan (miniPCR: Cambridge, MA)

Sponsoring Company: Center for BioMolecular Modeling

The discovery of CRISPR as an adaptive immunity system in bacteria marks a significant milestone in the development of molecular biosciences. This system has provided us with new tools with which we are now poised to begin editing the human genome. In this workshop, we will tell the story of the discovery of CRISPR as a group effort involving many research groups found in many countries around the world. We will then use the hands-on CRISPR Adaptive Immunity Kit to explore how this system functions to protect bacteria from infection by bacteriophages. We will also present teachers with ways to connect this new topic to foundational concepts that are already being taught in high school biology classrooms. Finally, we will introduce teachers to an engagement activity that challenges their students with the question – Could you have discovered CRISPR?

TAKEAWAYS:
Participants will understand how CRISPR functions as an adaptive immunity system in bacteria

SPEAKERS:
Tim Herman (3D Molecular Designs: Milwaukee, WI)

Sponsoring Company: Bio-Rad Laboratories

Dig into CRISPR, a revolutionary technology in gene therapy. Learn about a classroom CRISPR lab activity with robust controls and a free paper model.

TAKEAWAYS:
1. Learn about a lab activity in which students do real CRISPR gene editing and confirm the chromosomal edit with PCR; 2. Receive and practice using a free paper model to teach the function of Cas9, a key protein in CRISPR technology; and 3. Hear the latest in CRISPR technology, including current efforts in gene therapy.

SPEAKERS:
Leigh Brown (Bio-Rad Laboratories: Hercules, CA), Tamica Stubbs (Bio-Rad Laboratories: Hercules, CA)

Sponsoring Company: miniPCR bio

Demonstrate the power that molecular techniques bring to managing infectious disease outbreaks. In this case study, students act as healthcare providers at an airport screening facility and test fictional patients for infection with the SARS-CoV-2 virus. Students use PCR and a handheld P51 fluorescence viewer to diagnose their patients. The data for this lab can be collected two ways: endpoint detection or qPCR time point observations. Endpoint detection allows your students to use a single observation of fluorescence to diagnose their patients, in a single class period and without the need to run a gel. For longer classes, students can monitor their PCR samples over time to model the principles of qPCR, the gold standard for diagnosis of SARS-CoV-2 infection.

TAKEAWAYS:
Students act as healthcare providers at an airport screening facility and test fictional patients for infection with the SARS-CoV-2 virus and investigate the principles of qPCR in the classroom, in a single class period!

SPEAKERS:
Bruce Bryan (miniPCR: Cambridge, MA)

Sponsoring Company: Center for BioMolecular Modeling

The discovery of the CRISPR adaptive immunity system in bacteria has provided us with a powerful new tool with which we can begin to edit the human genome. The Cas9 endonuclease is able to bind to a specific unique site in the 3.2 billion base-pair human genome – and make a double-stranded cut. This sequence-specific cut is the first step in the process of genome editing. In this workshop we will explore the molecular mechanism of CRISPR Cas9, including the use of a guide RNA to program the nuclease to target a specific nucleotide sequence. Teachers will be introduced to a hands-on model – Cas9 Making the Cut – that can be used to introduce this topic to students. This Making the Cut Kit is designed to be used after the students are first introduced to the CRISPR system using the CRISPR Adaptive Immunity Kit. We will also explore how Cas9 is being engineered to become an even more powerful genome editing tool.

TAKEAWAYS:
Participants will learn how Cas9 can be programmed with guide RNA to recognized any specific sequence of DNA.

SPEAKERS:
Tim Herman (3D Molecular Designs: Milwaukee, WI)

Sponsoring Company: Bio-Rad Laboratories

See how you can teach both photosynthesis and cellular respiration with algae beads in one hands-on lab in the real-world context of algae blooms.

TAKEAWAYS:
1. Learn how to work with algae beads, a fast and easy-to-use model organism; 2. Walk through how students can measure and learn about both photosynthesis and cellular respiration in the same hands-on lab; and 3. See how students can develop scientific explanations of algae blooms and the dead zone in the Gulf of Mexico using their learned knowledge about photosynthesis and cellular respiration.

SPEAKERS:
Leigh Brown (Bio-Rad Laboratories: Hercules, CA)

Sponsoring Company: miniPCR bio

Allow students to explore CRISPR/Cas genome editing in a living organism! The Knockout! Lab gives students the knowledge and tools to disable, or knock out, a gene in bacteria. Students will transform bacteria with a plasmid that carries the Cas9 gene and a guide RNA that targets the lacZ gene, then use white/blue phenotypic screening to confirm successful gene knockout. Importantly, students can use PCR to verify at the genotypic level that gene targeting occurred. We will also feature free educational resources from miniPCR bio designed to make CRISPR/Cas accessible to biology students of all levels. Our free CRISPR/Cas paper models walk students through examples of cutting-edge research, as well as the clinical use of the CRISPR/Cas to cure sickle cell disease.

TAKEAWAYS:
Perform an authentic CRISPR/Cas gene knockout in your classroom, use optional PCR and gel electrophoresis to further verify phenotypic results, and try free CRISPR/Cas resources for your classroom

SPEAKERS:
Bruce Bryan (miniPCR: Cambridge, MA)

Sponsoring Company: 3D Molecular Designs

Participants will explore how phenomenon-driven inquiry is enhanced using rich 3D models that let students figure out answers to their own questions while engaged in science practices. First, anchor-level and lesson level storylines familiar to participants will be identified. Then questions students generate will be explored while noting instructional routines that help maintain inquiry are discussed. Models that can help students investigate cellular processes like signaling, differentiation, growth, repair, and reproduction, at the microscopic and molecular levels will be used for participants to interrogate their own conceptual models and reflect on their learning. Strategies for capturing and monitoring student learning will be shared along with suggestions for summative assessments that are three dimensional.

TAKEAWAYS:
Participants will explore how phenomenon-driven inquiry is enhanced using rich 3D models that let students figure out answers to their own questions while engaged in science practices.

SPEAKERS:
Kim Parfitt (3D Molecular Designs: Milwaukee, WI)

Sponsoring Company: Pivot Interactives

As veteran teachers, we know how challenging it is to create an active learning environment using phenomena & science practices on your own. Pivot Interactives makes active learning throughout the learning cycle easy with a dynamic platform that invites students to explore scientific phenomena freely. Teaching environmental science & earth science while actively & frequently engaging students meaningfully doesn’t have to be just a dream. Come learn about the newest ways Pivot interactives helps you overcome the challenges you face as an environmental science or earth science teacher, so you can create the classroom you’ve always envisioned. Hear from fellow teachers about how they transformed their classroom with active learning, scaffolding, personalized feedback, phenomena-based assessments, increased use of science practices, and increased access to phenomena.

TAKEAWAYS:
In this session, environmental science & earth science educators will see the newest ways Pivot Interactives gives them effective, streamlined tools to engage students with phenomena & science practices through active learning.

SPEAKERS:
Eric Friberg (Pivot Interactives: Minneapolis, MN)

Sponsoring Company: 3D Molecular Designs

Participants will assess their biggest challenge areas with respect to student misconceptions about chromosome structure and function, including mitosis. Traditional wet labs like planaria, fruit fly genetics, and C-fern growth will be used to contextualize the hands-on models’ utility throughout the school year. Next, foam puzzle chromosomes will be introduced and used to model a round of DNA replication in the cell cycle, resulting in 4 chromosomes. The processes of mitosis and meiosis will be modeled and compared, to invite inquiry about why the processes are different. Whole chromosomes will be related with molecular chromosome details to illustrate how DNA is wound into a chromosome structure. Nucleosome models will further highlight the wrapping of DNA around histone proteins to compact the genome for replication. Participants will be asked to share how they teach about genetic variation in their classes. Following a discussion of their challenges, we will model variation first using the puzzle chromosomes to generate “crossing over” events and next by using the molecular-detailed expanded chromosomes. Finally, inheritance of Hemoglobin will be highlighted and modeled and Punnett squares models will be enhanced through using the foam models. Throughout the activities, participants will be invited to engage in self-reflection and collaborative discussion.

TAKEAWAYS:
Hands-on experiences with multiple representations of chromosomes reveals student thinking.

SPEAKERS:
Kim Parfitt (3D Molecular Designs: Milwaukee, WI)