The Next Generation Science Standards (NGSS) transform the way we approach teaching science by reflecting how scientists think and work. When we involve students in phenomena and task them to explain and predict those phenomena, they discover the usefulness of science ideas as a means to make sense of the world. The pressing challenge for teachers of diverse classrooms is to construct a learning environment that provides access to science for students who are underserved and who may not see the purpose of science or view science as relevant to their lives. This chapter demonstrates three key points and guides teachers to construct science-learning environments informed by the NGSS case studies to immerse diverse students in making sense of phenomena. Teacher background information, standards, assessments, and references are provided. This book selection also includes the Table of Contents, About the Editors, Contributors, Preface, and Index.