This chapter first presents performance expectations that describe the competencies and content for instruction and assessment in a high school biology class. This is followed by a description of a teaching sequence that integrates the practices, core ideas, and crosscutting concepts through a series of investigations, activities, explanations, and presentations. Teacher background information, standards, assessments, and references are provided. This book selection also includes the Table of Contents, Foreword, Preface, About the Author, Introduction, Appendix D, and Index.