This chapter presents a case study on John Snow’s Research Into the Cause and Spread of Cholera using the discovery engineering process. In the lesson, students explore the 1854 cholera outbreak in London and analyze the work done by Dr. John Snow to understand the cause and spread of the disease. Students look at data and maps to see how Dr. Snow drew his conclusions. Finally, they use what they’ve learned along with online research to design or adapt technology to help prevent or lessen the spread of the disease. This lesson may be taught in beginner biology courses during a unit on understanding disease or epidemiology. A list of materials, teacher background information, teacher notes, references, resources, assessments, and standards are provided. This book selection also includes the Table of Contents, About the Authors, Acknowledgments, Introduction, and Index.