Many of the challenges of team teaching—such as communication, content knowledge, and joint instruction—are issues that all co-teachers must address; however, there are unique characteristics to the elementary classroom that must be navigated by successful co-teaching teams. These issues relate to the characteristics of elementary learners, the focus on learning to read, the scope of the elementary science curriculum, and how co-teaching may be done in the elementary classroom. These challenges for the elementary classroom are discussed in this chapter.