In this chapter, the authors hope to illustrate science instruction that focuses on real-world problems and features the science teacher performing a variety of research-based strategies during any given teaching segment. It is a major goal also of this chapter to describe how a relatively new chemistry teacher can focus on and achieve almost every National Science Education Standards (NSES) More Emphasis tenet while moving away from the Less Emphasis aspects of science teaching. Specifically, this chapter will attempt to explain how students solve their own real-world chemistry problems with the advent of what we will call the SLICK—Student Led Investigations in Chemical Knowledge.