This chapter explores how educational technology has changed and will continue to change the ways that teachers teach and students learn in classrooms of the 21st century. The chapter begins with a description of how students can learn from computers with tutoring systems and drill and practice software. Next, it explores the use of primary sources available on the internet, data sets, CD-ROMS, video, and animations that offers examples of how students learn with (rather than from) technology. Lastly, this chapter explores how preservice and in-service teachers can best be prepared for the educational technology challenges of 21st century classrooms.