Laboratory experiments are an essential component to the accelerated classroom and provide an interactive learning environment linking science concepts to “real world” observations. While the actual laboratory experiments or exercises will vary depending on the content or discipline, there are more general concerns that should be addressed, such as maintaining student safety, working with a lab partner, writing a lab report, attending field trips, and conducting independent research. When students with disabilities are part of the classroom, these concerns are still present and science teachers need to consider some slight alterations in how to plan, organize, and address these challenges. The suggestions offered in this chapter are simple to incorporate and many can be easily used with the entire class, thus providing all students with support for success.