Incorporation of technology into the advanced classroom has flourished as the national focus on success in STEM classes has accelerated. The assumption is that new technologies support student learning of scientific concepts and processes. Being receptive to new and current technologies will help many students with disabilities maximize learning opportunities. The discussion in this chapter provides an overview of important terminology, some examples of how current technologies can be used, and suggestions for working with the IEP team and instructional technologist. This discussion also provides an overview of the types and uses of technology to support students with disabilities in classrooms.