Asking questions might seem like a practice that is already in widespread use in today’s science classrooms. But the practice of “Asking Questions” as envisioned in the Next Generation Science Standards (NGSS) is not at all common. In this chapter, we examine student engagement in the science practice of asking questions. Questioning is a central part of the science and engineering practices. The commitment to making “figuring out” be the work of science classrooms means that we always need a focus for what we are trying to figure out. Questions will evolve and change as we learn more about what we are investigating. But articulating, revisiting, and evaluating progress toward questions is a central part of sharing the responsibility for knowledge building with students. A list of materials, teacher background information, standards, assessment, and references are provided. This book selection also includes the Table of Contents, About the Editors, Contributors, Acknowledgments, and Index.