Direct observation, measurement, indirect evidence, and inferential reasoning are used to uncover nature’s patterns and their underlying logic. Scientists use both data interpolation and extrapolation, as well as new technologies, to find ways to peer into and open nature’s structures of black boxes within black boxes. In this activity, learners are asked to predict the number of beads inside a projected image of an opaque box (or an actual 3-D box) based on an observable pattern of beads on a string that appears to go in one side and out the opposite side of the box.