Models are manageable representations of objects, concepts, and phenomena, and are everywhere in science. Models are “thinking tools” for scientists and have always played a key role in the development of scientific knowledge. Models of the solar system, the atom, and DNA are among the most well known, but models come in many forms, including physical constructions, mental and mathematical representations, and computer simulations. Scientists, engineers, and science educators would be lost without them. This issue of Science Scope has an excellent collection of articles that will be helpful to teachers who are looking for new ways to use models in their classrooms.