Assistive Technology (AT) can be any item, piece of equipment, or teacher-made product that is designed to improve a student’s functional capability or help a student succeed in accessing the general education curriculum. Lahm and Morrissette (1994) identify seven instructional areas in which AT has proven advantageous for use with students with mild disabilities: organization, note taking, writing assistance, productivity, access to reference materials, cognitive assistance, and materials modification. In this article, we discuss the application of a wide variety of AT in each of the seven instructional areas that are especially useful in the secondary science classroom with both special-needs and regular-education students.