Recent legislation, such as No Child Left Behind and the Individuals with Disabilities Education Act (IDEA) amendments of 1997 and 2004, emphasizes the importance of teaching students with mild disabilities in the general education classroom using the general curriculum. Due to the emphasis on high-level thinking skills, science courses may be particularly challenging for students with learning problems. This article summarizes some common characteristics of students with learning problems who typically take high school science courses and presents modifications for instruction to help these students and their teachers experience success.